
Chemical compounds with physical data, reactions and substructure search.
Chempirical API is a free Science & Math API that requires no API key, is served over HTTPS and supports CORS, so it can be called from the browser.
Free read-only JSON API for 48,000 compounds, reactions, Antoine constants and azeotropes: search, identifiers, physical data, structure images and reaction scaling.
Details from chempirical.com.

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The Chempirical API is provided by Chempirical (chempirical.com). Free read-only JSON API for 48,000 compounds, reactions, Antoine constants and azeotropes: search, identifiers, physical data, structure images and reaction scaling.
Yes. The Chempirical API is listed in the Science & Math category of the public-apis directory, which only includes APIs that are free or have a free tier. Check its documentation for rate limits and paid plans.
No. The Chempirical API requires no authentication, so you can start making requests without signing up.
Yes. The Chempirical API supports CORS, so front-end JavaScript can call it directly.
Yes. The Chempirical API is served over HTTPS, so it's safe to use in production.